Curative effect of large dose of ambroxol on patients with ventilator-associated pneumonia

OBJECTIVE To investigate the curative effect of large dose of ambroxol on the patients with ventilatorassociated pneumonia(VAP)and evaluate the effect and safety.METHODS Totally 71 VAP patients who were hospitalized the ICU of the Peking University Third Hospital from Feb through Oct were enrolled in the study,the patients were randomly divided into the general dose group(n=37)and the large dose group(n=34);then the general dose group was treated with ambroxol,the large dose group was treated with ambroxol,both of the treatment courses were 14days,then the indicators were compared between the two groups.RESULTS The difference in the white blood cell,neutrophil classification,clinical pulmonary infection score(CPIS)or oxygenation index between 7days and 14days after the treatment was significant(P0.05).The white blood cell,neutrophil classification and CPIS of the general dose group and the large dose group were decreased before the treatment or 7days or 14days after the treatment.The P value of the white blood cell,neutrophil classification and CPIS were respectively 0.002,0.049,and 0.002 7days after the treatment and were respectively 0.020,0.038,and 0.001 14days after the treatment,the difference was significant(P0.05);the oxygenation index showed an upward trend,there was significance 14days after the treatment(P0.05);the hospitalization duration of the general dose group was(42.68±19.85)d,the large dose group(26.76±14.41)d;the mechanical ventilation time of the general dose group was(27.11±8.60)d,the large dose group(19.18±10.30)d,showing an upward trend,the difference was significant(P0.05);the reintubation rate within 48hwas 10.81%in the general dose group,8.82%in the large dose group;the mortality was 29.73%in the general dose group,20.59%in the large dose group.CONCLUSIONLarge dose of ambroxol for the treatment of VAP can achieve significant clinical efficacy in shortening the duration of hospitalization as well as the duration of mechanical ventilation,with the reintubation rate and mortality lower than those of the general dose group.