Distribution and drug resistance of pathogens causing biliary tract infections

OBJECTIVE To investigate the distribution and drug resistance of pathogens causing biliary tract infections so as to provide guidance for clinical use of antibiotics.METHODS The bile samples that were collected from Jan 2008to Aug 2012were cultured with the use of BacT/ALERT120automated blood culture system,then the isolated pathogens were identified by using VITEK-2Compact automatic microorganism identification system,and the drug susceptibility testing was performed.RESULTS A total of 305strains of pathogens have been isolated, among which the gram-negative bacilli accounted for 69.84%,the gram-positive bacteria 27.54%,the fungi 2.62%;the Escherichia coli,Klebsiella pneumoniae,Enteroccocus faecalis,Enteroccocus faecium,and Pseudomonas aeruginosaranked the top 5species of pathogens,accounting for 29.18%,12.13%,11.48%,6.89%,and 5.90%,respectively.The detection rates of the extended-spectrum beta-lactamases(ESBLs)-producing E.coli and K.pneumoniae were 47.19% and 21.62%,respectively.The drug resistance rates of the E.coli to penicillin, quinolones,and some of the third generation cephalosporins varied between 48.86% and 69.32%,and the drug resistance rates to amikacin and imipenem were low;the drug resistance rates of the P.aeruginosato amikacin, gentamicin,and piperacillin-tazobactam were less than 12.00%;the drug resistance rate of the E.faecalis to linezolid was 2.94%,and no strains resistant to vancomycin or teicoplanin have been detected;the drug resistance rate of the E.faeciumto glycopeptides varied from 4.76%to 9.52%.CONCLUSION The gram-negative bacteria are the main pathogens causing biliary tract infections,and the mixed infections are common;the broad spectrum antibiotics susceptible to the E.coli are recommended for the treatment of biliary tract infections.