Distribution of pathogens causing biliary tract infections and drug resistance

OBJECTIVE To study and explore the distribution of pathogens causing biliary tract infections and drug resistance so as to provide basis for the clinical use of antibiotics.METHODS From Jan 2007 to Dec 2010,a total of 362 patients with biliary tract infections were collected for bacterial culture of bile,the isolation and identification of the pathogens and drug susceptibility testing were performed,the test results were analyzed.RESULTS A total of 231 strains of pathogens were isolated from 362 bile samples with the positive rate of 63.3%;gram-negative bacilli accounted for 68.8%,gram-positive cocci accounted for 26.0%,fungi accounted for 2.2%;the common pathogens causing biliary tract infections were Escherichia coli(29.0%),Enterococcus faecalis(15.2%),Klebsiella pneumoniae(10.8%),Enterobacter cloacae(9.5%),Acinetobacter baumannii(7.8%);drug susceptibility testing results showed that the drug resistance rates of gram-negative bacilli to imipenem,piperacillin/tazobactam,ampicillin,cefazolin,and sulfamethoxazole/trimethoprim were 0.6%,6.9%.94.3%,71.7%,and 51.6%,respectively;the resistance rates of gram-positive cocci to vancomycin,nitrofurantoin,and linezolid were 0,1.7%,and 3.3%;drug susceptibility of the fungi was good.CONCLUSION Gram-negative bacilli remain the pathogens causing baliary tract infections,the spectrum of the pathogens always changes,Acinetobacter and Enterobacter increase,and the drug resistance of the pathogens has been increased,it is necessary to strengthen the detection of the pathogens and the analysis of the drug resistance so as to reasonably use antibiotics.