Distribution and drug resistance of pathogens cultured from bile of patients with biliary tract infections

OBJECTIVE To investigate the distribution and drug resistance of 201strains of pathogens cultured from bile specimens obtained from the patients with biliary tract infections so as to provide guidance for reasonable clinical use of antibiotics.METHODS The clinical data of the patients with biliary tract infections who were treated from Jan 2010to Dec 2012were investigated,then the bile specimens were cultured,the identification of the pathogens was performed.RESULTS A total of 201strains of pathogens have been cultured from 312submitted bile specimens of the patients with biliary tract infections with the positive isolation rate of 64.4%,among which the gram-negative bacilli accounted for 66.2%,the gram-positive cocci 24.4%,the fungi 9.4%;among the isolated pathogens,the Escherichia coli ranked the first place,accounting for 45.3%(91strains),and the Enterococcus faecalis ranked the third place,accounting for 15.4%,(31strains).The drug susceptibility rate of the Enterobacteriaceae to carbapenems was 100.0%;the drug susceptibility rate of the E.faecalis to glycopeptides was100.0%;the drug resistance rates of the gram-negative bacilli to sulfamethoxazole-trimethoprim,gentamicin,cefotaxime,levofloxacin,and ciprofloxacin were more than 40.0%;the drug resistance rates to amikacin,imipenem,meropenem,cefoperazone-sulbactam,and piperacillin-tazobactam were less than 20.0%.The isolation rate of the extended-spectrumβ-lactamases(ESBLs)-producing bacteria was 42.5%.CONCLUSION Most of the pathogens causing biliary tract infections are the intestinal flora,and the drug resistance of the pathogens shows an upward trend.It is necessary for the hospital to strengthen the implementation of measures for clinical use and administration of antibiotics and improve the awareness of reasoanbel medication of the clinician so as to curb the rapid increase of bacterial drug resistance.