Characteristics and drug resistance of pathogens causing biliary tract infections

OBJECTIVE To explore the features and drug resistance of the pathogens causing biliary tract infections and to guide the rational drug use.METHODS The clinical data of 257 cases of patients with biliary tract infections were reviewed retrospectively.The culture,isolation,and identification of biliary samples were performed in regular routine.The drug susceptibility testing was performed by K-B disc diffusion method.RESULTS The positive culture rate was 70.04%(180/257).A total of 184 strains of pathogens were isolated,including112(60.87%) strains of gram-negative bacteria,68(36.96%)strains of gram-positive bacteria,and 41(2.17%) strains of fungi.The top 4 species of pathogens isolated were Escherichia coli(27.17%),Enterococcus faecalis(20.65%),Klebsiella pneumoniae(11.96%),and Enterococcus faecium(10.87%),which varied in the drug resistance to the commonly used antibiotics.The drug resistance rates of the gram-negative bacteria to cefoperazone/sulbactam were relatively low,the drug resistance rate to imipenem was 0%.The gram-positive bacteria showed no drug resistance to vancomycin,linezolid,and teicoplanin.CONCLUSION E.coli and Enterococci are the common species of pathogens causing biliary tract infections,their drug resistance is complex,the hospital should reasonably select the antibiotics based on the drug susceptibility testing.