Evaluation of the Efficacy of Insulin Combined with Metformin Tablets in the Treatment of Type 2 Diabetes Mellitus

Objective To investigate the clinical efficacy of insulin combined with metformin tablets for the treatment of type 2diabetes mellitus(T2DM). Methods 94 T2 DM patients were randomly divided into observation group and control group, 47 cases in each group. The control group received 30/70 mixture recombinant human insulin injection treatment, the observation group received metformin tablets treatment on the basis of the treatment given to the control group. And the efficacies of the two groups were compared. Results After treatment, the levels of FPG, 2h PG and Hb Alc of both groups were significantly lower than those before treatment(P0.05); and there were no significant differences between the two groups(P0.05); the MAGE of both groups decreased significantly after treatment, and MAGE of the observation group was significantly lower than that the control group(P0.05); there were no adverse reactions occurred in the observation group, but the incidence of adverse reactions of the control group was 10.64%, the difference between the groups was statistically significant(P0.05). Conclusion Insulin combined with metformin tablets has significant effect on T2 DM, which can improve the effect of glycemic control and reduce adverse reactions, so it is worthy of promotion and application.