Clinical observation of different dosages of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding

Objective To observe and compare the clinical effect of different dosages of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding. Methods 84 patients with perimenopausal dysfunctional uterine bleeding who were admitted and treated in our hospital from July 2011 to December 2012 were analyzed retrospectively. 42 patients were assigned to a group A, which was orally given 5.0 mg of mifepristone. Another 42 patients were assigned to a group B, which was orally given 10.0 mg of mifepristone. Total effective rate, relapse rate, incidence of adverse events, thickness of endometrium before and after the treatment, and levels of serum sex hormone in the two groups were compared. Results The total effective rates one month and three months after the treatment in the group B were both higher than those in the group A, and the relapse rate was lower than that in the group A. The thickness of endometrium in the group B was lower than that in the group A, and the level of serum sex hormone was also better than that in the group A. All the differences were statistically significant(P 0.05); the incidence of adverse events in the two groups were not significantly different(P 0.05). Conclusion 10.0 mg of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding has a better comprehensive curative effect and its safety can be assured.