Clinical Efficacy of Dahuang Zhechong Pill on Chronic Hepatitis with Hepatic Fibrosis

OBJECTIVE:To evaluate the clinical effect of Dahuang zhechong pill on chronic hepatitis with hepatic fibrosis.METHODS:A total of 128 patients with chronic hepatitis with hepatic fibrosis were randomly divided into treatment group(68 cases) and control group(60 cases).The control group received routine hepatic protective therapy,while the treatment group received routine hepatic protective therapy and Dahuang zhechong pills(6 g·d-1) concomitantly.The course of treatment lasted for 6 months.The clinical symptoms,liver function,hyaluronic acid(HA),pro-collagen Ⅲ(PC Ⅲ),cholyglycine(CG) and collagen type Ⅳ(ⅣC),and ultrasound image were observed in both groups.RESULTS:Levels of serum HA,PCⅢ,CG,and ⅣC decreased significantly in treatment group,and the difference between two groups was significant(P0.05).And in the treatment group,the clinical symptoms improved significantly,and the indexes ALT and AST etc decreased significantly as well.CONCLUSION:Dahuang zhechong pill was an effective drug for chronic hepatitis with hepatic fibrosis in that it can alleviate the symptom of hepatic fibrosis and improve the hepatic function.