The primary study of immunomodulatory effect of Jidesheng sheyao on mice

Objective:To study the immunomodulatory effect of Jidesheng Sheyao (JDS), a Chinese prepared medicine, on mice. Methods: 48 BALB-c mice were randomly divided into four groups: the normal control group, the model group, treatment group 1 and treatment group 2. The drugs were given by intragastric gavage in every group twice every day, lasting twenty-one days. The normal control group and the model group were given the same volume of normal saline, the mice of the other experimental groups were respectively treated with corresponding drug. From the 15th day,all experimental mice expect those of the normal control group were administered with the CY (30mg/kg,iH) for seven days. The 21th day after ig different doses of JDS an hour,the mice were sacrificed.Then the weights of spleen and thymus were measured.Effect of JDS on the BALB-c mouse spleen lymphocyte proliferation was detected by MTT assay.Result:In comparison with the model group, treatment groups manifested that the avoirdupois,the indexes of spleen and thymus were promoted;SI was increased significantly.Conclusion: JDS can increase the cell immune functions in immunodepressed mice.