The Expression of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 With Hypertensive Disorder Complicating Pregnancy

Objective To investigate the relationship between the expression of mat-rix metalloproteinase-2 and tissue inhibitor of metallopro teinase-2 in placenta of the patients with hypertensive disorder complicating pregnancy.Methods Placenta tissues were collected from the women with delivery in the Nanhua Affiliated Hospital of Nanhua University and genecology and Obstetics Hospital of Hengyan from Oct.2005 to Apr.2006.The total number is 52,and 16 of it is from the women with normal pregnancy(control team) and 36 of it is from the women with hypertensive disorder complicat-ing pregnancy syndrome(experimentation team).The expression of MMP-2 and TIMP-2 were examined by in situ hybridization. Results The expression of MMP-2 is significantly reduced in the placentas of women with hypertensive disorder complicating pregnancy(P0.01),but that of TIMP-2 has no significant difference(P 0.05).The expression of TIMP-2/MMP-2 is significantly increased in the placentas of women with hypertensive disorder complicating pregnancy(P0.01).Conclusion Decreased expression of MMP-2 and imbalance in TIMP-2/MMP-2 are related to invasive defect,abnormal vascular remodeling and hypertensive disorder complicating.These abnormal changes may be responsible for the placental pathological change.