Re-evaluation of Multi-tumor Marker Protein Biochip Detective System in Diagnosis of Primary Hepatocellular Carcinoma

Objective To re-evaluate the diagnostic value of multi-tumor marker protein biochip detective system for liver cancer,and to guide the proper application of the detection method in clinical diagnosis.Methods Using the multi-tumor markers protein biochip detective system to determine and analyze the concentration values of 12 tumor markers(CA19-9,NSE,CEA,CA242,CA125,CA153,AFP,Ferritin,f-PSA,PSA,β-HCG,HGH) in the serum levels of 99 liver cancer patients,93 benign liver disease patients and 90 healthy persons.Results By statistical analysis,we found that the concentrations of AFP,Fer,CA19-9,CA242 were all higher in the PHC group than in the non-PHC groups;the difference was significant;combined measurement of the above-mentioned four kinds of indicators,the positive ratio was 75%,had higher sensitivity than single tumor marker in the detective system.Conclusion In this study,adopting the multi-tumor marker protein chip detection system,the sensitivity of combined detection of liver cancer was only increased to 75%,lower than the sensitivity of 82.89%~91.6%,compared to more articles.