2010•Journal of Baotou Medical CollegeRequires access
Effect of Shunqibuxinshiyiwei Pill on Tumor Necrosis Factor-α in Myocardial Infarction Rats
QU Hong-ying
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Abstract
Objective: To investigate the expression of tumor necrosis factor-α(TNF-α) in experimental myocardial infarction rats with intervention of Shunqibuxinshiyiwei Pill.Methods: Myocardial infarction rat models were created with Isoproterenol(ISO) by hypodermic injection(40 mg/kg×2days).The rats in each group were treated with stomach affusion until 28th day.The rats pathological manifestation were clarified with HE staining and the expression of tumor necrosis factor-α in myocardium tissue were performed with immunohistochemistical staining on the 28th day after myocardial infarction in each group.Results: The pathological injury were significantly improved and the expression of tumor necrosis factor-α were significantly declined in the other three groups,compared with myocardial infarction group(P0.05).Conclusion: Mongolia drug-Shunqibuxinshiyiwei Pill could prevent ventricular remodeling by declining the expression of tumor necrosis factor-α in myocardial infarction rats.