2010•Unpublished venueRequires access

EFFECT OF SHUNQIBUXINSHIYIWEI PILL IN MYOCARDIAL INFARCTION RATS

Xiaolan Jiao

Abstract

Objective:To investigate expression of tumor necrosis factor-α(TNF-α)、matrix metalloproteinase-9(MMP-9)、transforming growth factor-β1(TGF-β1) in experimental myocardial infarction rats with intervention of Shunqibuxinshiyiwei Pill.Methods:Myocardial infarction rat models were created with Isoproterenol(ISO) by hypodermic injection.Each group were affused stomach respectively until 7th day.The rats pathological manifestation were clarified with HE staining and the expression of TNF-α、MMP-9、TGF-β1 in myocardium tissue were performed with immunohistochemistical staining at 7th day after myocardial infarction in each group.Results:The pathological injury were significantly improved and the expression of TNF-α、MMP-9、TGF-β1 were significantly declined in other three groups compared with myocardial infarction group(P0.05).Conclusion:Mongolia drug-Shunqibuxinshiyiwei Pill could prevent ventricular remodeling by declining the expression of TNF-α、MMP-9、TGF-β1 in myocardial infarction rats.

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Key concepts: Medicine, Myocardial infarction, Pathological, Internal medicine, Transforming growth factor, Tumor necrosis factor alpha, Infarction, Cardiology