Effects of RouKouWuWei Pill on Ventricular Remodeling following Myocardial Infarction in the Rats

Objective To study the effects of RouKouWuWei Pill on matrix metalloproteinases(MMPs) of left ventricular remodeling following myocardial infarction in the rats.Methods Thirty-six SD rats were randomly divided into normal control group、myocardial infarction group and Mongolian drug group.The rats of myocardial infarction group and drug-treated groups were given isoproterenol(ISO) by ip,subsequently drug-treated groups given Mongolian drug 1 g/kg·d by ig until this experiment terminal.Left ventricular weight indexes were calculated and the expression of MMPs were measured by SABC.The pathologic change of myocardium was observed with microscope.Results Left ventricular weight index and the expression of MMP-2,MMP-9 in the myocardial infarction group increased significantly compared with normal control.The weight index and the activities of MMPs decreased in Mongolian drug group compared with myocardial infarction group.(P0.05或P0.01).Conclusion The expression of MMPs in the interstitium increased in some trends following myocardial infarction,and this change may be the major cause of ventricular remodeling.The effects of Mongolian Drug RouKouWuWei Pill on the activities of MMPs may be one of mechanisms on the ventricular remodeling following myocardial infarction.