Study on pathogens causing lower respiratory tract infections and their drug resistance

Objective To ascertain the distribution and drug resistance of pathogens isolated from patients with a lower respiratory tract infection so as to provide evidence for infection control.Methods Strains isolated from clinical samples from patients in Respiratory Medicine in 2011 were retrospectively analyzed and the drug resistance of these pathogens was assessed.Results In total,174 strains of pathogens were isolated.Gram-negative bacteria were most prevalent,accounting for 45.98% of the pathogens,and mostly consisted of Pseudomonas aeruginosa(12.07%) and Klebsiella pneumonia(10.92%).Also prevalent were fungi,accounting for 27.59% of pathogens,and consisted mostly of Candida albicans(16.67%).Gram-positive bacteria were present,accounting for 26.44% of pathogens,and consisting mostly of Staphylococcus aureus(7.47%).Among Gram-negative bacteria,P.aeruginosa had resistance to meropenem of 14.29% and resistance to amikacin of 14.29%.K.pneumonia,Escherichia coli,and Acinetobacter baumannii had 0% resistance to meropenem and imipenem.Stenotrophomonas maltophilia had 0% resistance to sulfamethoxazole compounds,which was the lowest rate of resistance.Gram-positive bacteria were least resistant to vancomycin.Conclusion Fungi are increasingly responsible lower respiratory tract infections.The drug resistance of pathogens has increased to an extent.In clinical practice,antibiotics should be used rationally based on results of drug susceptibility testing.