Effect comparison of levamlodipine and amlodipine in treatment of hypertension

Objective To investigate effect of levamlodipine and amlodipine in treatment of hypertension. Methods A total of 115 cases of hypertension from May 2012 to January 2014 in our hospital were collected, and were randomly divided into control group(n =57) and observation group(n =58). The control group was given amlodipine besylate tablets treatment, while the observation group was given levamlodipine besylate tablets treatment. Adverse reaction, the change of blood pressure, the total curative effect of two groups were compared. Results After treatment, SBP and DBP levels of control group and the observation group had no significant difference(t=0.378, P=0.706; t=0.187, P=0.352).The effective rate of observation group was 84.5%, while the control group was 80.7%, and there was no significant difference between two groups(χ2=0.286, P=0.593). The adverse rate of observation group was 5.2%, which was lower than that of control group 21.1%(χ2=6.392, P=0.012). Conclusion Levamlodipine and amlodipine has a similar treatment effect for hypertension, but the levamlodipine has lower adverse reaction and higher security.