Clinical Effects of Carvedilol in Patients with Congestive Heart Failure

Objective: To evaluate the clinical effects and the mechanisms of carvedilol in patients with congestive heart failure (CHF, New York Heart Association functional class Ⅲ-Ⅳ ). Methods: Fifty-five CHF patients were randomly divided into two groups. One is conventional treatment group (n=26) treated with digitalis, diuretics, and vasodilatation including ACEI; and another is carvedilol treatment group (n=30) treated with carvedilol and conventional therapy. Echocardiogram, blood routine examination and blood biochemical examination were done bofore and after treatment. Result: After treated for three months, the cardiac function improved markedly in both groups, but that in carvedilol treatment group improved more significantly than that in conventional treatment group. Conclusion: Carvedilol has a cardiac protective effect in patients with congestive heart failure, in improving cardiac function and decreasing ventricular remodeling progress.