Drug Resistance Analysis of Pseudomonas aeruginosain Patients with Respiratory Trace Infection

OBJECTIVE To study resistance and the change of Pseudomonas aeruginosa of respiratory system infection,and offers basis for prevention of clinical infection and the reasonable use of drugs.METHODS The respiratory system infection patients from Jun 2007 to Dec 2008 were investigated.To the results of MICs with158 P.aeruginosa strains were analyzed.RESULTS A total of 158 strains of P.aeruginosa were isolated from 359 specimens,which accounted for 44.01%.Imipenem had the best antibiotic activity and with the lowest drug resistance rate(16.46%),followed by Piperacillin/Tazobactam(21.52%),Trimethop rim/Sulfa 100.00%,Ampicillin 100.00%,Cefazolin 100.00%.CONCLUSIONS The resistance of the isolates is serious.For the reason that we should strengthen monitoring of resistance,choose reasonably to apply antibiotics in order to reduce drug-resistant strains.and to establish a drug resistance monitoring system to prevent hospital infection,detect the pathogenic bacteria and use antibiotics rationally.