Effects of Xuefu Zhuyu decoction on intercellular adhesion molecule and lipid peroxidation of experimental atherosclerosis rats

To investigate the effects of Xuefu Zhuyu decoction on intercellular adhesion molecule and lipid peroxidation of atherosclerosis rats.40 SD rats were randomly divided into control group,model group and Xuefu Zhuyu high-dose group,Xuefu Zhuyu low dose group and Xuezhikang group.The control group was fed with normal diet,model group was fed with high fat diet,the treatment group was fed with high fat diet and given treatment drugs.12 weeks later,the expression of ICAM-1 proteinum in the endarterium of AS rats was detected by immunohistochemical technique,SOD and MDA of serum were tested.ICAM-1 of model group expression levels showed a strong positive expression,the treatment group showed a weak positive expression(P0.05),compared with model group,the serum contents of SOD in test group were increased,while MDA were decreased significantly(P0.05).Experiment showed Xuefu Zhuyu decoction could decrease the regulation of ICAM-1 expression,remove lipid peroxides,protect endothelial cells,prevent and treat atherosclerosis.