The Effect and Mechanism of Xuefu Zhuyu Decoction on the Rats with Atherosclerosis

Objective To investigate the effect and mechanism of xuefu zhuyu decoction on rats with atherosclerosis.Methods Forty SD rats were randomly divided into the control,model,xuefu zhuyu and xuezhikang groups,with 10 rats in each.The group was fed with normal diet,the model was fed with high fat diet,while the treatment groups were fed with high fat diet and drugs.After 12 weeks,the rats were sacrificed.The expression of MMP-2 protein in the endarterium of AS rats was detected by immunohistochemical technique.the level of hs-CRP was detected by full automatic biochemical analyzer.the MCP-1 was detected by ELISA method.Results The level of MMP-2,hs-CRP and MCP-1 increased significantly in the model group(P0.05),but decreased in the treatment group(P0.05).Conclusion Xuefu zhuyu decoction can improve elasticity of blood vessels and inhibit expression of inflammatory factor so as to prevent and treat atherosclerosis,the mechanism of which may be associtated with decreasing the expression of MMP-2,hs-CRP and MCP-1.