Clinical observation of prevention of postpartum hemorrhage in cesarean section with misoprostol

Objective To observe the effects of misoprostol in prevention of postpartum hemorrhage in cesarean section. Methods Two hundred parturients women undergoing cesarean sections were randomized into two groups. Misoprostol group(n = 100) :400 μg misoprostol was given by anal administration immediately after cesarean section;Oxytocin group (n = 100) :20 U oxytocin was given by intravenous drip immediately after cesarean section. The amount of bleeding within 2 h and 24 h after delivery,the blood pressure and the side effects after using medicine was observed. Results The mean amount of bleeding in misoprostol group within 2 h and 24 h was much less than that in oxytocin group (P 0. 05 ) ; there was no significant differences in blood pressure between two groups ( P 0. 05);there was no significant difference in the side effects between two groups (P 0. 05). Conclusion Misoprostol is more effective in prevention of postpartum hemorrhage in cesaream section than oxytocin.