Combination of Misoprostol and Oxytocin for Prevention of Hemorrhage after Cesarean Section

Objective To observe the clinical effects of the combination of misoprostol and oxytocin in the prevention of hemorrhage after cesarean section. Methods We divided 326 cases of cesarean section in our hospital randomly into experimental group(175 cases)and control group(151 cases). The experimental group received the sublingual administration of Misoprostol 200μg immediately after the open peritoneal,then the injection of Oxytocin 20U in uterus and the intravenous injection of 5%GS 500mL+Misoprostol 30U immediately after fetus was removed. The control group was injected with Oxytocin 20U in uterus with the intravenous injection of 5%GS 500mL + Misoprostol 30U immediately after fetus was removed. The volume of bleeding in both groups at 2h and 24h after cesarean section were measured. Results The volume of bleeding was(220.65±44.93)mL at 2h and (363.65±52.07)mL at 24h after cesarean section in the experimental group,while (271.47±50.38)mL at 2h and(414.53±51.74)mL at 24h after cesaean section in the control group,respectively. There was a significant difference between the two groups(P0.05). Conclusion The combination of misoprostol and oxytocin in the prevention of bleeding after cesarean section is more effective than the single use of Oxytocin and it is easy to use misoprostol,safe and particularly suitable for primary hospitals.