A Clinical Study on Misoprostol Administered Rectally in the Prevention of Hemorrhage after Cesarean Section

Objective:To observe the preventing effect of misoprostol on hemorrhage after cesarean section. Methods:Three hundred and fifty patients receiving cesarean sections were randomized into two groups:misoprostol group (n=176), 600 μg misoprostol was given rectally when anesthesia was successfully performed; oxytocin group (n=174), 20 U oxytocin was injected into uterine muscle immediately after delivery of baby. The bleeding amount within 24 hours after delivery was measured. Results:The bleeding amount within 2 hours and from 2 to 24 hours after delivery in misoprostol group were lower than those in oxytocin group [respectively, (289.3±83.3) mL vs. (338.4±88.5) mL, and (54.1±14.2) mL vs. (75.1±22.8) ml, P0.05]. The incidence of hemorrage in misoprostol group was also lower than that in oxytocin group (9.7% vs. 25.9%, P0.05). Conclusion:Misoprostol is more effective than that of oxytocin in reduction of cesarean section.