Clinical Significance of Changes of Serum Cholinesteruse,Alkaline Phosphatase and Prealbumin in Patients with Sepsis

Objective To explore the clinical significance of changes of serum cholinesteruse(ChE),alkaline phosphatase(ALP) and prealbumin(PAB) in patients with sepsis.Methods A total of 72 patients with sepsis in our hospital from July 2010 to July 2012 were selected and APACHE Ⅱ score was calcumulated.The fasting serum level of cholinesterase,alkaline phosphatase and prealbumin were detected in 24 hours at the admission day and the 3rd day.Then the patients were divided into group A(APACHEⅡscore 20,n=33) and group B(APACHEⅡscore≥20,n=39),with the incidence of multiple organ dysfunction syndrome(MODS) and mortality rate compared.The patients were divided into non-MODS group(n=51) and MODS group(n=21).In addition,the patients were divided into survival group(n=45) and death group(n=27) according to the prognosis.ChE,ALP and PAB in each group were compared.Results The incidence of MODS and mortality rate in group B were significantly higher than those in group A(P0.05).ChE and PAB of the patients in MODS group in 24 hours at the admission day and the 3rd day were significantly lower than those in non-MODS group(P0.05);The same results were got in death group and survival group(P0.05);There was no significant difference of ALP(P0.05).Conclusion The measurement of cholinesterase and prealbumin is useful to evaluate the severity of illness and the prognosis of the patients with sepsis.