The relationship between fasting serum levels of prealbumin and the prognosis of AECOPD in the elderly

Objective To explore the correlation between fasting serum levels of prealbumin(PAB)and the prognosis of acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)in the elderly.Methods Simplified acute physiology score (SAPS)Ⅱ 0f 100 elderly AECOPD patients were calculated on the first day of diagnosing AECOPD and fasting venous blood samples were drawn on the next morning to detect the levels of PAB. l00 patients were divided into group A(SAPS Ⅱ 20-30),group B(SAPS Ⅱ 30 -40)and group C (SAPS Ⅱ≥40). The correlation between the serum levels of PAB and prognosis was analyzed.Then the patients were divided into survival group and death group? according to the prognosis. The serum levels of PAB and SAPS Ⅱ score were compared between these two groups ,too.Results The mortality rate of the three groups had significant difference (0% vs 5% vs 34%,P 0.01),the serum levels of PAB was higher in group A((200.05±64.49) mg/l than that of group B(173.79±42.47) mg/l and group C(127.70±42.22) mg/l (P 0.05),while the serum levels of PAB in group B was higher than that of group C(P 0.05).The SAPS Ⅱ score of death group(24.52±8.00)was higher than that of survival group(16.65±4.11)(P 0.01),and the serum levels of PAB of death group(156.21±73.95) mg/l was lower than that of survival group(192.10±73.76) mg/l (P 0.01).Conclusions The serum levels of PAB has clinical significance in evaluating the prognosis of AECOPD in elderly.The patients with lower serum levels of PAB has higher mortality rate.