The relationship between fasting serum levels of prealbumin and the prognosis of SIRS in the elderly

Objective To explore the correlation between fasting serum levels of prealbumin (PAB) and the prognosis of systemic inflammatory response syndrome (SIRS) in the elderly. Methods The scores of acute pathologic and chronic health evaluation (APACHE) Ⅱ of 111 elderly SIRS patients were calculated on the first day of diagnosing SIRS, and fasting venous blood samples were drawn on the next morning to detect the levels of PAB. 111 patients were divided into group A (APACHEⅡ10-16), group B (APACHEⅡ 17-21) and group C (APACHEⅡ≥22),to analyze the correlation between the serum levels of PAB and prognosis. Then the patients were divided into survival and death groups to analyze the serum levels of PAB and APACHEⅡ score. Results The mortality of three groups had significant difference(21.62% vs 62.16% vs 81.08%,P0.05),the serum levels of PAB was higher in group A (230.00±79.66) g/L than that of group B (160.44±61.40)g/L and group C (127.70±42.22)g/L (P0.05), and that of group B was higher than that of group C (P0.05). The APACHEⅡscore of death group (24.52±8.00)was higher than that of survival group (16.65±4.11) (P0.01), and the serum levels of PAB of death group (156.21±73.95) g/L was lower than that of survival group (192.10±73.76)g/L (P0.01). Conclusions The serum levels of PAB has clinical significance in evaluating the prognosis of SIRS in elderly. The patients with lower serum levels of PAB has higher mortality.