Clinical significance of serum PAB changes in hospital-acquired pneumonia

Objective:To explore the clinical significance of changes of serum prealbumin(PAB) in hospital-acquired pneumonia(HAP).Methods:75 patients with HAP were selected and evenly divided into 3 groups according to the simplified acute physiology score(SAPS)Ⅱ,group A(SAPSⅡ scores 20-30),group B(SAPSⅡ scores 30-40) and group C(SAPSⅡ scores40),25 cases in each group.The serum levels of PAB,total protein(TP) and albumin(ALB),and prognosis were analyzed among 3 groups.After 2 weeks,the patients were redivided into survival group and death group according to prognosis.Fasting serum levels of PAB,TP and ALB and SAPSⅡ scores were compared between two groups.Results:Comparing 3 groups,fasting serum level of PAB in group A was obviously higher than that of group B and C.Group B was higher than group C(P0.05).But the changes of TP and ALB had no statistical significance.The SAPSⅡ scores of the death group were higher than those of the survival group.The fasting serum level of PAB of the death group was lower than that of the survival group.But the changes of TP and ALB showed no statistical significance.Conclusion:Fasting serum level of PAB may be used as a sensitive index in evaluating inflammation control of HAP,which has some clinical significance in estimating the disease condition and prognosis.