Evaluation of the effect and security on fentanyl-propofol and midazolam-propofol in gastroscopy

Objective To evaluate the sedative and analgesic effect and the security of fentanyl-propofol and midazolam-propofol in gastroscopy.Methods The patients undergoing gastroscopy were randomly divided into three groups:fentanyl-propofol group (group I),midazolam-propofol group (group Ⅱ) and control group(group Ⅲ).The reaction of patients,the effect of sedation and analgesia,the variation of Bp,HR,SPO 2 and SDNN during examination were observed.Questionnaires were proceeded after gastroscopy.Results Patients in groupⅠand Ⅱ felt much less discomfortable than group Ⅲ(P0.05),and also the time of gastroscopy in groupⅠand Ⅱ is shorter (P0.05).The BP and HR during gastroscopy in group Ⅲ increased significantly and the SDNN decreased remarkablely compared with those of patients before the examination,but in groupⅠand Ⅱall the BP,HR and SDNN during gastroscopy decreased slightly.The time of patients coming into unconsciousness and the time of patients regaining consciousness in groupⅠwere shorter than groupⅡ(P0.01).Conclusion Fentanyl-propofol and midazolam-propofol could make gastroscopy more effective,more comfortable and safer.Fentanyl-propofol was more suitable for sedative and analgesic gastroscopy than midazolam-propofol.