Study on extraction of berberine hydrochloride and preparation condition of dropping pills

OBJECTIVE Berberine hydrochloride refining get tasted preparation,research into dropping of the preparation of technological factors,and get the best preparation process.METHODS To drop distance,dripping speed,solution temperature and cooling fluid temperature as investigation factors to dissolve variable time limit,exterior quality and pills heavy differences as evaluation index,using the orthogonal experiment design optimization of dropping prescriptions and molding process.RESULTS To extract and refined income of berberine hydrochloride for apis to PEG6000 for matrix,with liquid paraffin wax as coolant,when matrix during melting,preparation of berberine hydrochloride dropping in medicine:matrix for comforteth,dropper caliber,solution temperature for 2mm for 70℃,dripping speed for the 40d·min-1,dripping from 7cm,cooling fluid for the temperature is 2℃ for optimum condition.CONCLUSION Preparation of income,dropping time small scattered soluble appearance quality good pill heavy differences,accord with small dropping quality requirements,and can be used in the preparation of berberine hydrochloride dropping.