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2010•The Chinese Journal of Modern Applied PharmacyRequires access

Study on Preparation Process for Wuweizi Dropping Pills

Jin Yu, Cui Baiji, Xiurong Zhang

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Abstract

OBJECTIVE To study the preparation technology of Wuwerzi dropping pills by orthogonal design.METHODS Time limit of dissolution,grain roundness and weight variation were used as comprehensive evaluation indexes for selecting good dropping conditions.RESULTS The best pills formatting process were the ratio of PEG 4000 to PEG6000(1:1),the ratio of Wuwerzi to matrix was 1:4,the dripping temperature was 85 ℃,methylsiliconoil was used as refrigerant with the temperature of 10 ℃.The moulding probability was highest.CONCLUSION The optimized moulding process results in high finished product rate and good quality which are suitable for the preparation of Wuwerzi dropping pills.

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What this paper is about

OBJECTIVE To study the preparation technology of Wuwerzi dropping pills by orthogonal design.METHODS Time limit of dissolution,grain roundness and weight variation were used as comprehensive evaluation indexes for selecting good dropping conditions.RESULTS The best pills formatting process were the ratio of PEG 4000 to PEG6000(1:1),the ratio of Wuwerzi to matrix was 1:4,the dripping temperature was 85 ℃,methylsiliconoil was used as refrigerant with the temperature of 10 ℃.The moulding probability was highest.CONCLUSION The optimized moulding process results in high finished product rate and good quality which are suitable for the preparation of Wuwerzi dropping pills.

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Available abstract

OBJECTIVE To study the preparation technology of Wuwerzi dropping pills by orthogonal design.METHODS Time limit of dissolution,grain roundness and weight variation were used as comprehensive evaluation indexes for selecting good dropping conditions.RESULTS The best pills formatting process were the ratio of PEG 4000 to PEG6000(1:1),the ratio of Wuwerzi to matrix was 1:4,the dripping temperature was 85 ℃,methylsiliconoil was used as refrigerant with the temperature of 10 ℃.The moulding probability was highest.CONCLUSION The optimized moulding process results in high finished product rate and good quality which are suitable for the preparation of Wuwerzi dropping pills.

Key concepts: Roundness (object), Materials science, Process engineering, PEG ratio, Chromatography, Mathematics, Composite material, Chemistry

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