2008•Qilu Pharmaceutical AffairsRequires access

Study on formation technology of Berberine Hydrochloride Dropping Pills

Lanjiang Zhou

Abstract

OBJECTIVE To optimize the technical parameters through controlling the different factors.METHODS Dissolution,appearance and weight variation was used as comprehensive evaluation indicator to select good prescriptions and dropping conditions.RESULTS The optimized preparation conditions were as follows: PEG1000+ PEG4000(1∶1) was optimal bases,optimal drugs and bases is 1∶4,temperature of mixture is 95℃,dropping speed is 50 drop ·min-1,5℃ dimethylsilicone oil is condensate,dropping distance is 6cm.CONCLUSION The highest finished product with good quality can be got through this process.

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Key concepts: Berberine hydrochloride, Chemistry, Process engineering, Process (computing), Dissolution, Drop (telecommunication), Mathematics, Chromatography