Evaluation of left ventricular function in patients with subclinical diabetic cardiomyopathy by quantitative tissue velocity imaging.

Objective:To assess global left ventricular systolic and diastolic function in patients with subclinical diabetic cardiomyopathy by quantitative tissue velocity imaging(QTVI).Methods:QTVI was performed in Sub-DCM (n=30) and healthy subjects (n=30) at apical long-axis,two chamber and four chamber view. The peak systolic velocity (Vs) and early diastolic relaxation velocity (Ve) and late diastolic velocity (Va) were measured at 6 mitral annular sites with QTVI software. Mean Ve and mean Va as well as mean Vs were calculated and to compare with left ventricular ejection fraction (LVEF) and peak filling rate (PFR) which were calculated from the equilibrium radionuclide ventriculography.Results:Ve and MVe of 6 annular sites and PFR in Sub-DCM were lower than that of healthy subjects (P0.05) , but Vs and MVs and LVEF were not significantly different (P0.05) ,so did Va and MVa.There was a significant positive correlation between MVs and LVEF in Sub-DCM(r=0.89,P0.01),the correlation between MVe(r=0.72,P0 01)and MVa(r=0.62,P0.01)and PFR was good.Conclusion:Left ventrivular early diastolic function is impaired while left systolic function is nomal in Sub-DCM.Mitral annular motion velocities were measured by QTVI could be used to evaluate left global systolic and diastolic function.