Evaluation on Curative Effect of Continue Subcutaneous Insulin Injection(CSII) of Insulin Aspart or Novolin R on 68 Cases with Diabetic Ketoacidosis

Objective To observe clinical curative effect of continue subcutaneous insulin injection(CSII) of Insulin Aspart or Novolin R on patients with diabetic ketoacidesis.Methods Sixty-three patients with diabetic ketoacidesis were divided into the Insulin Aspart group(n=32) and the Novolin R group(n=36) randomly.A comparison was made among the recovering time of blood glucose and plasm pH and the disappearing time of urinary ketobodies,the dosages of insulin and the frequency of hypoglycemia incidence.The both of target is the fasting plasma glucose(FPG)7.0 mmol/L and the 2 h postprandial plasma glucose(2 hPG) 10.0 mmol/L.Results The blood sugar obviously declined in each group.There was no significant difference in the average recovering time of blood glucose between two groups(t=0.262 6,P0.05).The disappearing time of urinary ketobodies and the recovering time of plasm pH in the Insulin Aspart group were significantly shorter than that in the Novolin R group(t=19.454 0,P0.05).The insulin dosages in the Insulin Aspart group was as well less than that in the Novolin R group(t=2.007 0,P0.05).The frequency of hypoglycemia incidence in the Insulin Aspart group was significantly lower than that in the Novolin R group(t=12.244 0,P0.01).Conclusions The CSII can imitate effectively the human physical insulin secreting,and it is more safe and valid in the treatment on diabetic ketoacidesis.