THE EFFECTS OF SSF ON LEARNING AND MEMORY IN MICE

Objective:To study of SSF on learning and memory in mice. Methods:The mice water maze performance was used to evaluate the effects of SSF on learning and memory and memory impairment of consolidation induced by NaNO 2 in mice. Piracetam (PIR) was used as reference drug. Results: During 5d acquisition trails, compared with saline control, SSF (100, 200mg/kg, ig, 12d) could significantly reduce the escape latency to find platform and the number errors entering non exit. No marked impact was found administration of PIR at dose of 200mg/kg in mice. NaNO 2 (120mg/kg, ip) consistently result in an increase the escape latency to find platform and the number errors entering non exit as compared with saline treated control. All the PIR (200mg/kg, ig,) and SSF (50, 100 and 200mg/kg, ig) could significantly lessen the increased latency and number errors. Conclusion : SSF could enhance learning and memory and ameliorate the impaired memory of consolidation induced by NaNO 2 in mice.