Improving effects of brevisvapine on chemicals-induced memory impairment in mice

Purpose To study the effect of breviscapine on memory acquisition and consolidation deficits induced by some chemicals.Methods The mice water maze was used to evaluate the effect of brevis-capine on memory acquisition and consolidation impairment of mice induced by carbrital sodium and NaNO2.The latency to find terminal platform and the number of errors entering non-exits in water maze were measured to assess the memory performance.Results During 5 d memory acquisition trial,15 mg/kg carbrital sodium obviously inhibited the memory acquisition and 120 mg/kg NaNO2 significantly induced the mice memory consolidation impairment.Aiministration of 5,10 and 20 mg/kg breviscapine for 5 d could reduce the increased latencies and number of errors induced by carbrital and NaNO2 in the water maze.Conclusion Breviscapine may make improvement in the learning and memory deficits of mice caused by carbrital sodium and NaNO2.