The effect of brain cell active factor on learning and memory of mice

Objective To study the effect of Brain Cell Active Factors (BCAF) on raising and improving learning and memory of mice. Methods 4-month-age mice were tested by using the modified Morris water maze, and were divided into learning and memory obstacle group (A. B), learning and memory deficit group (C. D) and learning and memory normal group and learning and memory normal adding scopolamine group (G. H). Every group mice again were divided into BCAF treated group (B. D. F. H. ) and normal saline (NS) control group (A. C. E. G.). Treated for 14 days, mice were analyzed the parameter of place navigation test by Morris water maze. Results 1) In BCAF treated mice of B. D and F groups, the escape latency of mice was significantly shortened after treatment compared with them before treatment (P0.001). 2) In NS control groups (A. C. G), the escape latency had no significant change in mice after treatment compared with them before treatment (P0.5, P0.2, P0.2). 3) The escape latency had significant difference in mice in NS control A group compared with them in BCAF treated B group after treatment (P0.02). 4) The escape latency had no significant change in mice in BCAF adding scopolamine treated group (H.) compared with them in NS adding scopolamine control group(G) before and after treatment(P0.2,P0.1). Conclusion BCAF can raise and improve learning and memory of mice, particularly improve learning and memory in learning and memory obstacle mouse.