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2009•Medical Journal of the Chinese People's Armed Police ForcesRequires access

Protective effects of propofol on renal injury during liver ischemia/reperfusion

Tiantian Wang

Open publisher page 2 citations

Abstract

Objective To investigate the remote renal injury induced by reactive oxygen species(Ros)after liver ischemia/reperfusion and the mechanism of renal protection afforded by propofol.Methods 72 male SD rats were randomly divided into three groups.The animals were killed after 60 minutes ischemia of liver followed by reperfusion for 2 hours and 4 hours.SOD and malondialdehyde(MDA)were detected.Results In I/R group MDA level increased significantly after I/R as compared with the baseline value before liver I/R,while propofol decreased the level of MDA significantly.In liver I/R group,blood SOD activity decreased significantly after I/R as compared with the baseline value before liver I/R,while propofol increased the SOD activity.Conclusions Propofol reduces the generation of ROS during liver I/R and protects kidney against ROS-induced injury.

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What this paper is about

Objective To investigate the remote renal injury induced by reactive oxygen species(Ros)after liver ischemia/reperfusion and the mechanism of renal protection afforded by propofol.Methods 72 male SD rats were randomly divided into three groups.The animals were killed after 60 minutes ischemia of liver followed by reperfusion for 2 hours and 4 hours.SOD and malondialdehyde(MDA)were detected.Results In I/R group MDA level increased significantly after I/R as compared with the baseline value before liver I/R,while propofol decreased the level of MDA significantly.In liver I/R group,blood SOD activity decreased significantly after I/R as compared with the baseline value before liver I/R,while propofol increased the SOD activity.Conclusions Propofol reduces the generation of ROS during liver I/R and protects kidney against ROS-induced injury.

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Available abstract

Objective To investigate the remote renal injury induced by reactive oxygen species(Ros)after liver ischemia/reperfusion and the mechanism of renal protection afforded by propofol.Methods 72 male SD rats were randomly divided into three groups.The animals were killed after 60 minutes ischemia of liver followed by reperfusion for 2 hours and 4 hours.SOD and malondialdehyde(MDA)were detected.Results In I/R group MDA level increased significantly after I/R as compared with the baseline value before liver I/R,while propofol decreased the level of MDA significantly.In liver I/R group,blood SOD activity decreased significantly after I/R as compared with the baseline value before liver I/R,while propofol increased the SOD activity.Conclusions Propofol reduces the generation of ROS during liver I/R and protects kidney against ROS-induced injury.

Key concepts: Propofol, Malondialdehyde, Medicine, Ischemia, Reperfusion injury, Anesthesia, Kidney, Reactive oxygen species

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