Experimental study about the protective effect of propofolon on acute renal ischemia reperfusion injury in rats

Objectives To investigate the renal protection and mechanism of propofol in acute renal ischemia reperfusion injury(ARIRI) rat models. Methods The model of rat's ARIRI was established. 63SD rats were randomly divided into 3 groups: false operating group(A group), ischemia reperfusion group (B group) and propofoi group(C group). Blood urea nitrogen (BUN), creatinine (Cr), superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were detected before I/R (Ischemic reperfusion) for 15 minutes and after I/R for2 hours and 24 hours, and renal histopathology lesions were examined.Results Renal histopathology lesions of Propofol preconditioning group decreased significantly after ischemia reperfusion. In L/R group, BUN and Cr serum levels increased significantly after ischemia reperfusion compared with false operating group(p ＜0.05), while propofol decreased the serum levels of BUN and Cr significantly (p ＜0.05). There was statistic significance of the serum levels of SOD, MDA, TNF-a and IL-6 in Propofol preconditioning group and ischemia reperfusion group (p ＜ 0.05). Conclusions Propofol preconditioning to kidney could protect the kidney from acute renal ischemia reperfusion injury. Key words: Kidney;  Reperfusion;  Rats;  Phenols