Clinical Observation of Nalmefene Hydrochloride in the Treatment of Acute Alcohol Toxicity Coma

OBJECTIVE:To observe clinical efficacy and safety of Nalmefene hydrochloride in the treatment of acute alcohol toxicity coma. METHODS:90 cases of acute alcohol toxicity coma were randomly divided into observation group and control group. Control group was given naloxone hydrochloride 0.8 mg added into 0.9% Sodium chloride injection 20 ml at 1 mg/min,and then received naloxone hydrochloride 0.8 mg added into 0.9% Sodium chloride injection 250 ml intravenously. Observation group was given Nalmefene hydrochloride 0.2 mg added into 0.9% Sodium chloride injection 10 ml at 1 mg/min,and then received conventional rehydration therapy 1 500 ml intravenously. Clinical efficacy of 2 groups was observed in 2 groups 1 h,2 h and 3 h after treatment,and the changes of respiration,heart rate and blood pressure were recorded before and after treatment,and awake time, discharge time and ADR were recorded in 2 groups. RESULTS:1 h,2 h and 3 h after treatment,total effective rate of observation group was significantly higher than that of control group,and awake time and discharge time of observation group were significantly lower than those of control group;there was statistical significance(P0.05). There was no obvious change in respiratory, heart rate and blood pressure,and no other obvious ADR was found during treatment. CONCLUSIONS:Nalmefene hydrochloride is effective and safe in the treatment of acute alcohol toxicity coma.