The clinical efficacy of banazapril accompanied with metoprolol for treatment of congestive heart failure

Objective:To evaluate the clini ca l therapeutic efficacy of banazapril accompanied with metoprolol for treatment o f congestive heart failure (CHF).Method:Two hundred patients with CHF were randomized to ta ke banazapril (5～10 mg per day)and metopolol( 6.25～100 mg per day,n=50) and to placebo (n=100) on the basis of conventional treatment. The mean peri ods of follow up was 327 days and the efficacy was assessed by meaans of echocar diography and clinical symptoms.Result:There were more signficant improvement in NYHA func tional class in banazapril accompanied with metoprolol group than in placeebo gr oup. Banazapril and metoprolol were associated with greater overall reduction o f left ventricular end-diastolic diameter and an overall increase in the LVEF% during the first year of therapy.Conclusion:Long term addition of banazapril and metoprolol to standard therapy may profoundly improve cardiac function and prevent clinica l deterioration in patients with CHF when compared with patients without metopro lol and banazapril treatment.