2013•Jilin Journal of Traditional Chinese MedicineRequires access
Effect of Qiongyu Oral Liquid on the Contents of Brain Tissue SOD and Serum SOD and MDA in the Aging Rats
Zhe Wen
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Abstract
Objective To study the effect of Qiongyu oral liquid on contents of brain tissue SOD and serum SOD and MDA in the aging rats.Methods The rats were divided into 6 groups randomly:control group,the aging model group,the positive control group and Qiong Yu oral low,medium and high dose group.The rats in each group were injected daily into subcutaneous neck with D-galactose(0.5 g/kg)to produce sub-acute rats model of aging,the rats in control group were injected with normal saline excpet the blank group.At the same time from the first day the rats were perfused the stomach with medicine,after continuous administration of six weeks the brain tissue and serum,enzyme-linked immunosorbent assy(ELISA) were taken out to detect SOD,MDA content.Results compared with the control group,model control group,SOD activity in brain tissue,blood SOD levels decreased significantly(P0.01),serum MDA levels were significantly increased(P0.01).Conclusion Qiongyu oral liquid can significantly improve brain tissue SOD activity and lower serum MDA content,increased free radical damage the body's defense capability,enhance organ index,with anti-lipid peroxidation role,which suggest that Qiongyu oral liquid have anti-aging effect.