2011•Unpublished venueRequires access
Study on changes of Prothrombin mRNA and PAR-1 mRNA expression in focal cerebral infarction in rats and intervening effects of Ziyin Huoxue Jiedu decoction
Duan Chun-yan
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Abstract
Objective To observe the changes of Prothrombin mRNA and PAR-1 mRNA expression in focal cerebral infarction in rats and intervening effects of Ziyin Huoxue Jiedu decoction.Methods Twenty-four rats were randomly divided into 4 groups: the sham-operated,model,Ziyin Huoxue Jiedu decoction and Argatroban groups.Each group was divided into two time phase point of 1st day and 3rd day.The MCAO models were reproduced.The expression of prothrombin mRNA and PAR-1 mRNA in brain tissue were detected.Results Compared with the sham-operated group,the expression of prothrombin mRNA and PAR-1 mRNA in brain tissue in model group were significantly higher(P0.01),the expression of prothrombin mRNA and PAR-1 mRNA were lowered significantly in Ziyin Huoxue Jiedu decoction group and Argatroban Injection group(P0.01).Conclusion Ziyin Huoxue Jiedu decoction is effective to restrain the expression of prothrombin mRNA and PAR-1 mRNA in brain tissue and reduce thrombin toxic injury.