STUDY ON THE PROPERTIES OF A RAPID HAND-DISINFECTANT SOLUTION

Objective To investigate the related properties of a rapid hand-disinfectant solution in order to provide the basis for the practical application.Methods The physical and chemical analysis method,suspension quantitative germicidal test,field disinfection trial and animal test were used to carry out laboratory and field observation.Results This rapid hand-disinfectant solution contains 1560 mg/L polyhexamethylene biguanidine and 50%(v/v) ethanol.The average killing log value of Staphylococcus aureus,Pseudom onas aeruginosa and Escherichia coli in suspension exposed to the stock solution of the disinfectant for 0.5 min was 5.00,that of Candida albicans was 4.00.The minimal eligible concentration in capacity test was 20%.When the hands were disinfected by wiping with the disinfectant solution for 1 min,the average reducing log value of the natural bacteria on skin and hands was 1.00.Its mouse oral LD_50 was 5000 mg/kg·bw and the average skin irritation score was 0.The mouse bone marrow poly chromatic erythrocyte micronucleus test was negative.Conslusion This rapid hand-disinfection solution exhibits good disinfection efficacy for vegetative form of bacteria and fungi.It is innoxious and non-irritating to skin.