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ATRA Combined with Arsenic Trioxide for Acute Promyelocytic Leukemia:A Clinical Study

Zheng Qiongbo

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Abstract

Objective To study the effect of all-trans retinoic acid(ATRA)combined with arsenic trioxide for acute promyelocytic leukemia.Methods 24 cases were selected who had been diagnosed with acute promyelocytic leukemia,by the way of clinical diagnosis,blood,bone marrow,cell immunity,cellular genetics and other tests.One group was treated with ATRA combined with arsenic trioxide,another group was treated with arsenic trioxide.Clinical effective was compared between two groups.Results Laboratory parameters and complete remission rate of combined group were better than monotherapy group,there was significant difference between two groups(P0.05).Conclusion ATRA pluses arsenic trioxide for acute promyelocytic leukemia,can increase complete remission rate and survival rate,which is an effective treatment method.

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What this paper is about

Objective To study the effect of all-trans retinoic acid(ATRA)combined with arsenic trioxide for acute promyelocytic leukemia.Methods 24 cases were selected who had been diagnosed with acute promyelocytic leukemia,by the way of clinical diagnosis,blood,bone marrow,cell immunity,cellular genetics and other tests.One group was treated with ATRA combined with arsenic trioxide,another group was treated with arsenic trioxide.Clinical effective was compared between two groups.Results Laboratory parameters and complete remission rate of combined group were better than monotherapy group,there was significant difference between two groups(P0.05).Conclusion ATRA pluses arsenic trioxide for acute promyelocytic leukemia,can increase complete remission rate and survival rate,which is an effective treatment method.

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Available abstract

Objective To study the effect of all-trans retinoic acid(ATRA)combined with arsenic trioxide for acute promyelocytic leukemia.Methods 24 cases were selected who had been diagnosed with acute promyelocytic leukemia,by the way of clinical diagnosis,blood,bone marrow,cell immunity,cellular genetics and other tests.One group was treated with ATRA combined with arsenic trioxide,another group was treated with arsenic trioxide.Clinical effective was compared between two groups.Results Laboratory parameters and complete remission rate of combined group were better than monotherapy group,there was significant difference between two groups(P0.05).Conclusion ATRA pluses arsenic trioxide for acute promyelocytic leukemia,can increase complete remission rate and survival rate,which is an effective treatment method.

Key concepts: Arsenic trioxide, Acute promyelocytic leukemia, Medicine, Leukemia, Retinoic acid, Tretinoin, Arsenic, Internal medicine

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ATRA Combined with Arsenic Trioxide for Acute Promyelocytic Leukemia:A Clinical Study — Research Paper | ScholarLens