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2013•Journal of Baotou Medical CollegeRequires access

Clinical Analysis of Therapeutic Effects in 32 Cases with Acute Promyelocytic Leukemia

Feng Yu

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Abstract

Objective: To observe the clinical efficacy of the chemotherapy regimen with all-trans retinoic acid(ATRA) combined with arsenic trioxide in adult patients with acute promyelocytic leukemia.Methods: The clinical data of 32 newly diagnosed patients with acute promyelocytic leukemia were retrospectively analyzed,and the remission rate,early mortality rate,and complications were compared between the cases treated with ATRA(ATRA group) and the patients treated with ATRA combined with srsenic trioxide(combination group).Results: The difference in remission rate was not significant between two groups,but the time required for complete remission in combination group was significantly shorter than in ATRA group.Conclusion: For the patients with acute promyelocytic leukemia,the clinical efficacy of ATRA combined with arsenic trioxide is better than that of ATRA.ATRA combined with arsenic trioxide chemotherapy regimen is worthy of promotion.

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What this paper is about

Objective: To observe the clinical efficacy of the chemotherapy regimen with all-trans retinoic acid(ATRA) combined with arsenic trioxide in adult patients with acute promyelocytic leukemia.Methods: The clinical data of 32 newly diagnosed patients with acute promyelocytic leukemia were retrospectively analyzed,and the remission rate,early mortality rate,and complications were compared between the cases treated with ATRA(ATRA group) and the patients treated with ATRA combined with srsenic trioxide(combination group).Results: The difference in remission rate was not significant between two groups,but the time required for complete remission in combination group was significantly shorter than in ATRA group.Conclusion: For the patients with acute promyelocytic leukemia,the clinical efficacy of ATRA combined with arsenic trioxide is better than that of ATRA.ATRA combined with arsenic trioxide chemotherapy regimen is worthy of promotion.

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Available abstract

Objective: To observe the clinical efficacy of the chemotherapy regimen with all-trans retinoic acid(ATRA) combined with arsenic trioxide in adult patients with acute promyelocytic leukemia.Methods: The clinical data of 32 newly diagnosed patients with acute promyelocytic leukemia were retrospectively analyzed,and the remission rate,early mortality rate,and complications were compared between the cases treated with ATRA(ATRA group) and the patients treated with ATRA combined with srsenic trioxide(combination group).Results: The difference in remission rate was not significant between two groups,but the time required for complete remission in combination group was significantly shorter than in ATRA group.Conclusion: For the patients with acute promyelocytic leukemia,the clinical efficacy of ATRA combined with arsenic trioxide is better than that of ATRA.ATRA combined with arsenic trioxide chemotherapy regimen is worthy of promotion.

Key concepts: Arsenic trioxide, Acute promyelocytic leukemia, Medicine, Regimen, Internal medicine, Tretinoin, Gastroenterology, Clinical efficacy

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