Analysis of drug resistance of Acinetobacter baumannii strains isolated from 2009 to 2011 in the third grade class A hospital

Objective To investigate the distribution and drug resistance of Acinetobacter baumannii strains. Methods Clinical isolation and drug sensitivity test of Acinetobacter baumannii in the First People′s Hospital of Changzhou from Jan 2009 to Dec 2011 were retrospectively analyzed. Results A total of 3 360 Acinetobacter baumannii were isolated, which was one of the top three pathogenic bacteria from 2009 to 2011. Acinetobacter baumannii was primarily isolated from lower respiratory tracts of the patients mainly from department of intensive care unit(ICU), departments of respiratory, neurosurgery and neurology. The drug resistance rate to imipenem, meropenem and piperacillin-tazobactam increased from 55.52%, 56.53% and 70.01% in 2009 to 79.70%, 77.61% and 79.76% in 2011, respectively. The difference was statistically significant. Conclusion There were obviously increasing tread in the drug resistant rates of Acinetobacter baumannii from 2009 to 2011. It is difficult to clear Acinetobacter baumannii strains. Resistance surveillance of Acinetobacter baumannii, standard use of antibiotics, disinfection and isolation work should be strengthened to prevent epidemic outbreaks.