Clinical distribution and trend of drug resistance of Acinetobacter baumannii causing infections in consecutive 11 years in Shenzhen

Objective To understand the distribution characteristics and drug resistance of Acinetobacter baumannii,so as to provide reference for rational use of antibiotics and infection control.Methods The results of drug susceptibility and clinical distribution of Acinetobacter baumannii from Jan 2001 to Dec 2011 in Shenzhen People′s Hospital were retrospectively analyzed.The variations of isolation rate and resistance rate were analyzed by WHONET 5.4.Results Acinetobacter baumannii infections were mainly distributed at ICU wards and respiratory wards,accounting for 43.89% and 24.49% respectively;Most strains were isolated from sputum specimens(70.30%).The isolation rates of Acinetobacter baumannii and multi-drug resistant strains showed an increasing trend,so did the resistance rates of Acinetobacter baumannii to 15 commonly used antibacterial drugs,which increased sharply in 2009 and remained high in 2010 and 2011.Pan-drue resistant strains appeared in 2011,and the isolation rate was 57.55%.The resistance rate and medium rate of Acinetobacter baumannii to Ampicillin-Sulbactam,Cefperazone-Sulbactam and Minocycline also increased obviously in last three years.Conclusion The drug resistance of Acinetobacter baumannii is severe;the isolation rates of multi-drug and pan-drug resistant Acinetobacter baumannii are increasing sharply.Infection control should be enhanced in ICU and respiratory department.