Analysis on results of Down's syndrome screening in 2046 pregnant women in second trimester in Wuhan

Objective: To explore the value of Down's syndrome screening in second trimester for detecting the abnormal fetuses and analyze the relationship between the maternal age and the risk for Down's syndrome screening.Methods: The study detected the concentration of AFP,HCG and uE3 in serum of pregnant women in second trimester(gestational week: 14-22) by chemiluminescence assay;estimated the risk of Down's syndrome,Edward's syndrome and neural tube defect by software.The cases were divided into two groups according to the age;and the risks in the two groups were compared.Results: Among 2046 cases,there were 179 cases with high risk for screening(136 cases with high risk for Down syndrome,15 cases with high risk for Edward's syndrome,29 cases with high risk for neural tube defect).The results of prenatal diagnosis showed that there were 4 cases with Down syndrome,1 case with Edward's syndrome,2 cases with neural tube defect,and 2 cases with other chromosome abnormality.The rate of high risk for Down's syndrome screening in the two groups was significantly different by statistical analysis.Conclusion: Down's syndrome screening in pregnancy trimester is the effective method for screening fetal birth defects.As the number of pregnant women with advanced maternal age gradually increases,the risk of abnormal fetuses increases.This should cause the attention of the appropriate departments,and it's also the new problem which the prenatal and postnatal care faces.