Screening of Down's Syndrome of 3128 Pregnant Women during the Second Trimester

Objective To evaluate the efficiency of screening down's syndrome in the second-trimester pregnant women.Methods Serum levels of AFP、β-HCG and uE3 were measured by microparticle chemiluminescent smmunoassay.In 3128 pregnant women during 14～21 weeks,and the risk rate was analyzed with the Down's syndrome program,the high-risk pregnant women were proposed to take fetal amniotic fluid or high resolution ultrasound examination.Results The high-risk rules for Down's syndrome,18-trisomy syndrome and neural tube defects were 5.58%,0.41%,1.32% respectively;there were five Down's syndrome,one 18-trisomy syndrome and four neural tube defects,three other chromosomal abnormalities by prenatal diagnosis.Conclusion Screening Down's syndrome of second-trimester pregnant is a major to prevent chromosomal disease and neural tube defects,the precise gestational age is the most important factor in the screening software.