Analysis of pregnancy outcome of pregnant women at high risk for Down syndrome screening

Objective:To investigate the value of Down syndrome screening at 2st trimester and analysis the relationship of high risk for Down syndrome screening and adverse pregnancy outcome.Methods: The study detected the concentration of AFP,HCG and uE3 in serum of pregnant women at 2st trimester(gestational week: 14-22) by chemiluminescence assay;estimated the risk of Down's syndrome,Edward's syndrome and neural tube defect by software;screened pregnant women with high risk.Acquire the pregnancy outcome through tracing the results of prenatal diagnosis and calling back.Results: Among 179 cases with high risk for Down syndrome screening,there were 4 cases with Down syndrome,1 case with Edward's syndrome,2 cases with neural tube defect,2 cases with other chromosome abnormality,3 cases with other malformation by ultrasound,and 1 case with abortion after amniotic cavity puncture.Conclusion: High risk for Down syndrome screening is a very sensitive indicator,which hints that the fetus may be with abnormality.Spreading the screening is important for reducing the rate of birth defect and improving the population quality.